Breast cancer risk associated with polymorphism in CYP19 in Japanese women
β Scribed by Yasuo Miyoshi; Kyoko Iwao; Noriko Ikeda; Chiyomi Egawa; Shinzaburo Noguchi
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- French
- Weight
- 62 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0020-7136
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Long-term exposure to oestrogens is a well-recognised risk factor for breast cancer, whereas little is known about the influence of polymorphisms of genes involved in oestrogen biosynthesis and metabolism. A candidate, containing a single bp polymorphism, T8C, (designated, A2 allele), might be the C
CYP17 encodes the enzyme cytochrome P-450c17β£, which mediates both 17β£-hydroxylase and 17,20-lyase in the steroid biosynthesis pathway. A polymorphism in the 5 promoter region of the CYP17 gene has been described. Steroid hormones, especially androgens, are believed to play a key role in the etiolog