𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Is CD81 the key to hepatitis C virus entry?

✍ Scribed by Charles M. Rice

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
34 KB
Volume
29
Category
Article
ISSN
0270-9139

No coin nor oath required. For personal study only.

✦ Synopsis

Chronic hepatitis C virus (HCV) infection occurs in

about 3 percent of the world's population and is a major cause of liver disease. HCV infection is also associated with cryoglobulinemia, a B lymphocyte proliferative disorder. Virus tropism is controversial, and the mechanisms of cell entry remain unknown. The HCV envelope protein E2 binds human CD81, a tetraspanin expressed on various cell types including hepatocytes and B lymphocytes. Binding of E2 was mapped to the major extracellular loop of CD81. Recombinant molecules containing this loop bound HCV and antibodies that neutralize HCV infection in vivo inhibited virus binding to CD81 in vitro. COMMENTS

πŸ“œ SIMILAR VOLUMES

Scavenger receptor class B type I is a k
Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81
✍ Mirjam B. Zeisel; George Koutsoudakis; Eva K. Schnober; Anita Haberstroh; Hubert πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 612 KB

Hepatitis C virus (HCV) is a major cause of chronic hepatitis worldwide. Scavenger receptor class B type I (SR-BI) has been shown to bind HCV envelope glycoprotein E2, participate in entry of HCV pseudotype particles, and modulate HCV infection. However, the functional role of SR-BI for productive H

T cell costimulation by the hepatitis C
T cell costimulation by the hepatitis C virus envelope protein E2 binding to CD81 is mediated by Lck
✍ Elisabetta Soldaini; Andreas Wack; Ugo D'Oro; Sandra Nuti; Cristina Ulivieri; Co πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 371 KB

## Abstract Binding of the hepatitis C virus (HCV) envelope protein E2 to CD81 provides a costimulatory signal for human T cells. This phenomenon may play a role in liver damage and autoimmune manifestations associated with HCV infection. Here we show that cross‐linking of CD81 by HCV E2 induced a

A model for the study of hepatitis C vir
A model for the study of hepatitis C virus entry
✍ ValΓ©rie Castet; Darius Moradpour πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 111 KB πŸ‘ 1 views

The study of hepatitis C virus (HCV), a major cause of chronic liver disease, has been hampered by the lack of a cell culture system