T cell costimulation by the hepatitis C
T cell costimulation by the hepatitis C virus envelope protein E2 binding to CD81 is mediated by Lck
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Elisabetta Soldaini; Andreas Wack; Ugo D'Oro; Sandra Nuti; Cristina Ulivieri; Co
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Article
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2003
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John Wiley and Sons
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English
⚖ 371 KB
## Abstract Binding of the hepatitis C virus (HCV) envelope protein E2 to CD81 provides a costimulatory signal for human T cells. This phenomenon may play a role in liver damage and autoimmune manifestations associated with HCV infection. Here we show that cross‐linking of CD81 by HCV E2 induced a