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Binding of the hepatitis C virus envelope protein E2 to CD81 provides a co-stimulatory signal for human T cells

✍ Scribed by Andreas Wack; Elisabetta Soldaini; Chien-Te K. Tseng; Sandra Nuti; Gary R. Klimpel; Sergio Abrignani


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
190 KB
Volume
31
Category
Article
ISSN
0014-2980

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T cell costimulation by the hepatitis C
✍ Elisabetta Soldaini; Andreas Wack; Ugo D'Oro; Sandra Nuti; Cristina Ulivieri; Co 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 371 KB

## Abstract Binding of the hepatitis C virus (HCV) envelope protein E2 to CD81 provides a costimulatory signal for human T cells. This phenomenon may play a role in liver damage and autoimmune manifestations associated with HCV infection. Here we show that cross‐linking of CD81 by HCV E2 induced a