## Abstract The extreme 5β²βproximal sequence of the hepatitis C virus (HCV) genome including the 5β² nonβcoding region (5β²NCR) of 341 nucleotide long and the first 30 nucleotides of the core region is highly conserved among different HCV genotypes. It contains a segment termed Internal Ribosome Entr
A Modular Approach to Synthetic RNA Binders of the Hepatitis C Virus Internal Ribosome Entry Site
β Scribed by Maia Carnevali; Jerod Parsons; David L. Wyles; Thomas Hermann
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 326 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1439-4227
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## Abstract The initiation of translation in hepatitis C virus (HCV) occurs at the internal ribosome entry site (IRES) located at the 5β²βend of its genomic RNA. To study the function of HCV IRES, we constructed a reporter plasmid that generates a bicistronic mRNA encoding two fluorescent proteins:
The extreme 5-proximal sequences of the hepatitis C virus RNA concentrations in patients with chronic HCV-1b infection. (HEPATOLOGY 1997;26:1616-1620.) (HCV) genome including the 5untranslated region (5UTR) and the first 30 nucleotides of the core region are highly conserved, and serve as an interna