IPEX,FOXP3and regulatory T-cells: a model for autoimmunity
β Scribed by Hans D. Ochs; Eleonora Gambineri; Troy R. Torgerson
- Book ID
- 107572270
- Publisher
- Springer-Verlag
- Year
- 2007
- Tongue
- English
- Weight
- 218 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0257-277X
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Mutations of forkhead box p3 (__FOXP3__), the master gene for naturally occurring regulatory T cells (nTregs), are responsible for the impaired function of nTregs, resulting in an autoimmune disease known as the immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. The rel
## Abstract FOXP3 is a specific marker for naturally occurring regulatory T cells (nTreg). FOXP3 expression is correlated with development and function of nTreg. Recent evidence suggests that, upon activation, human effector T (Teff) cells and type 1 regulatory T (Tr1) cells can express FOXP3, albe