FOXP3: Not just for regulatory T cells anymore
✍ Scribed by Steven F. Ziegler
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 102 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
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## Abstract FOXP3 is a specific marker for naturally occurring regulatory T cells (nTreg). FOXP3 expression is correlated with development and function of nTreg. Recent evidence suggests that, upon activation, human effector T (Teff) cells and type 1 regulatory T (Tr1) cells can express FOXP3, albe
## Abstract The transcription factor FOXP3 is critical for development and function of regulatory T cells (Treg). Their number and functioning appears to be crucial in the prevention of autoimmunity and allergy, but also to be a negative prognostic marker for various solid tumors. Although expressi