Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts
β Scribed by Sokolov, Mykyta V; Smilenov, Lubomir B; Hall, Eric J; Panyutin, Igor G; Bonner, William M; Sedelnikova, Olga A
- Book ID
- 110069928
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 336 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0950-9232
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The induction of DNA strand breaks in human dip-respectively). Using these two methods, the SSBs/ loid fibroblasts (VH-10) was demonstrated after in DSBs ratio was estimated to be 148 for PO and 44 vitro exposure with two carcinogenic epoxides, pro-for ECH. pylene oxide (PO) and epichlorohydrin (ECH
The repair kinetics of DNA single-and double-PO, respectively, were rejoined within 4 hr after the strand breaks (SSBs, DSBs) induced with two carcin-treatment (a half-life of Γ2.5 hr), with little further ogenic epoxides, propylene oxide (PO) and epichl-repair thereafter. At lower dose of ECH (1 mM