✦ LIBER ✦

Ion-exchange resins for solution phase parallel synthesis of chemical libraries

✍ Scribed by Leah M. Gayo; Mark J. Suto

Book ID: 104256108
Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 202 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(96)02362-3

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✦ Synopsis

Described are various techniques that employ ion-exchange resins for the solution-phase synthesis of chemical libraries. We have found these resins to be useful as reagents and/or scavengers in a variety of reactions. Nine basic ion-exchange resins were evaluated for the catalysis and purification of an amide synthesized from an acid chloride. A number of the resins examined provided products in >95% purity.

Acidic ion-exchange resins were also useful as scavengers in the synthesis of ureas. A demonstration of the utility of these resins for the preparation of amide, ester and urea libraries is also described.

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