Parallel solution phase synthesis of N-substituted 2-pyrazoline libraries

✍ Scribed by Udo Bauer; Bryan J Egner; Ingemar Nilsson; Marie Berghult

• Book ID: 104210109
• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 148 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)00246-x

✦ Synopsis

The value of α,β-unsaturated ketones (chalcones) as templates for the combinatorial assembly of N-substituted 2-pyrazolines has been explored. Based on a set of 80 chalcones, an array of 1500 N-carbamoyl, carbonyl and sulfonyl pyrazolines were produced demonstrating that a broad range of diversity can be fabricated around the pyrazoline motif. The efficient utilization of polymer-supported reagents and scavengers aided in providing typical purities of 75-98%.