✦ LIBER ✦

Novel N-demethylation of ketolide: application to the solution phase parallel synthesis of N-desosaminyl-substituted ketolides using ion exchange resins

✍ Scribed by Alexis Denis; Christelle Renou

Book ID: 104251164
Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 181 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00746-3

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✦ Synopsis

A series of N-desosaminyl-substituted ketolides was synthesized in parallel by reductive amination of various aldehydes by a N-desmethyl-ketolide scaffold followed by a solid phase extraction protocol using ion exchange resins. In addition, we have demonstrated that diethyl azodicarboxylate (DEAD) can be used efficiently as a N-demethylating reagent to access to N-desmethyl-ketolides.

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ChemInform Abstract: Novel N-Demethylati

ChemInform Abstract: Novel N-Demethylation of Ketolide: Application to the Solution Phase Parallel Synthesis of N-Desosaminyl-Substituted Ketolides Using Ion Exchange Resins.

✍ Alexis Denis; Christelle Renou 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 24 KB 👁 2 views

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