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Iodinated tracers for imaging amyloid plaques in the brain

✍ Scribed by Hang F Kung; Mei-Ping Kung; Zhi Ping Zhuang; Catherine Hou; Chi-Wan Lee; Karl Plössl; Bing Zhuang; Daniel M Skovronsky; Virginia M.-Y Lee; John Q Trojanowski


Book ID
116747880
Publisher
Springer-Verlag
Year
2003
Tongue
English
Weight
489 KB
Volume
5
Category
Article
ISSN
1536-1632

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A new series of diphenylpropynone (DPP) derivatives for use in vivo to image β-amyloid (Aβ) plaques in the brain of patients with Alzheimer's disease (AD) were synthesized and characterized. Binding experiments in vitro revealed high affinity for Aβ (1-42) aggregates at a K(i) value ranging from 6 t