Iodinated tracers for imaging amyloid plaques in the brain
✍ Scribed by Hang F Kung; Mei-Ping Kung; Zhi Ping Zhuang; Catherine Hou; Chi-Wan Lee; Karl Plössl; Bing Zhuang; Daniel M Skovronsky; Virginia M.-Y Lee; John Q Trojanowski
- Book ID
- 116747880
- Publisher
- Springer-Verlag
- Year
- 2003
- Tongue
- English
- Weight
- 489 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1536-1632
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## Abstract In a search for new probes to detect β‐amyloid plaques in the brain of patients with Alzheimer′s disease, the radioiodinated quinoxaline derivative (I) is found to show specific labeling of Aβ plaques.
A new series of diphenylpropynone (DPP) derivatives for use in vivo to image β-amyloid (Aβ) plaques in the brain of patients with Alzheimer's disease (AD) were synthesized and characterized. Binding experiments in vitro revealed high affinity for Aβ (1-42) aggregates at a K(i) value ranging from 6 t