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Involvement of urokinase-type plasminogen activator in smooth muscle cell migration in vitro

✍ Scribed by P.H.A. Quax; M.J. Wijnberg; A.C.W. de Bart; J.H. Verheijen

Book ID: 118325955
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 110 KB
Volume: 115
Category: Article
ISSN: 0021-9150
DOI: 10.1016/0021-9150(95)96354-u

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## Abstract Urokinase‐type plasminogen activator (uPA) binds to its receptor, uPAR, on the surface of cancer cells, leading to the formation of plasmin. Rhabdomyosarcoma (RMS) cell lines secrete high levels of insulin‐like growth factor II (IGF‐II), suggesting autocrine IGFs play a major role in th