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Urokinase-type plasminogen activator is involved in smooth muscle cell migration in wounded cultures

✍ Scribed by P.H.A. Ouax; I.M.S.L. Khouw; T.R. Bakker; R.T.J. van Leeuwen; J.H. Verheiien


Book ID
119154727
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
136 KB
Volume
8
Category
Article
ISSN
0268-9499

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## Abstract Urokinase‐type plasminogen activator (uPA) binds to its receptor, uPAR, on the surface of cancer cells, leading to the formation of plasmin. Rhabdomyosarcoma (RMS) cell lines secrete high levels of insulin‐like growth factor II (IGF‐II), suggesting autocrine IGFs play a major role in th