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Involvement of the HMGI(Y) gene in a microfollicular adenoma of the thyroid

✍ Scribed by Paola Dal Cin; Alfredo Fusco; Gazanfer Belge; Gennaro Chiappetta; Monica Fedele; Patrick Pauwels; Jörn Bullerdiek; Herman Van den Berghe

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
258 KB
Volume
24
Category
Article
ISSN
1045-2257

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✦ Synopsis

Follicular thyroid adenomas are epithelial tumors characterized by subgroups with specific chromosomal aberrations. Here we present a case with translocation t(1;6)(p35;p21). In 1p35 and 6p21, two genes of the high-mobility group of proteins are located. With P1-derived Artificial Chromosome (PACs) derived from the HMG17 gene located at 1p35 and HMGI(Y) located at 6p21, fluorescence in situ hybridization was performed. The breakpoints were located distal to HMG17 and proximal to HMGI(Y), but no rearrangement of the genes was shown by FISH. However, an overexpression of the HMGI(Y) gene was detected by RT-PCR as well as by immunohistochemistry techniques. This suggests a breakpoint in the proximity of the HMGI(Y) deregulating HMGI(Y) gene expression, a situation found in a variety of human benign mesenchymal tumors with involvement of chromosome band 6p21.

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