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Involvement of the cyclin-dependent kinase-4 inhibitor (CDKN2) gene in the pathogenesis of lymphoid blast crisis of chronic myelogenous leukaemia

โœ Scribed by Anna Serra; Enrico Gottardi; Fulvio Della Ragione; Giuseppe Saglio; Achille Iolascon


Book ID
114714303
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
539 KB
Volume
91
Category
Article
ISSN
0007-1048

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## Abstract Defects in the system controlling the cell cycle can lead an increased proliferation of cancer cells. The aim of our study was to analyze the relationship between genetic changes leading to inactivation of the __CDKN2A__ gene and subsequent alteration of protein expression in squamous c