Cyclin-dependent kinillre-4 inhibitor genes (INK4) regulate the cell cycle and are candidate tumor-suppressor genes. To determine if alterations in the coding regions of the p18 and p l 9 genes, which are novel members of the INK4 family and if they correlate with the development of human cancer, 10
β¦ LIBER β¦
Studies of variations of the cyclin-dependent kinase inhibitor 1C and the cyclin-dependent kinase 4 genes in relation to type 2 diabetes mellitus and related quantitative traits
β Scribed by Eva-Maria D. Nielsen; Lars Hansen; Trine Stissing; Keiko Yanagisawa; Knut Borch-Johnsen; Pernille Poulsen; Allan Vaag; Torben Hansen; Oluf Pedersen
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 200 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0946-2716
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## Communicated by Haig Kazazian Mutations in the homeodomain-containing transcription factor hepatocyte nuclear factor-1 Ξ² Ξ² (HNF-1 Ξ² Ξ² ) are known to cause a rare subtype of maturity-onset diabetes of the young (MODY5), which is associated with early-onset progressive non-diabetic renal dysfunct