Treatment of hepatocellular carcinoma (HCC) by chemotherapy is often impeded by the intrinsic multidrug resistance (MDR) of this frequent primary cancer of the liver. The MDR phenotype can be caused by ATP-dependent export of chemotherapeutic drugs across the plasma membrane being mediated by transp
Involvement of sulfate conjugation and multidrug resistance-associated protein 2 (Mrp2) in sex-related differences in the pharmacokinetics of garenoxacin in rats
β Scribed by Tamon Hayashi; Fumie Abe; Miki Kato; Hiroko Saito; Jun Ueyama; Yuya Kondo; Kuniyuki Imai; Miki Katoh; Masayuki Nadai; Takaaki Hasegawa
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 240 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1341-321X
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We have studied regulation of the multidrug resistance protein 2 (mrp2) during bile duct ligation (BDL) in the rat. In hepatocytes isolated after 16, 48, and 72 hours of BDL, mrp2-mediated dinitrophenyl-glutathione (DNP-GS) transport was decreased to 65%, 33%, and 33% of control values, respectively