## Abstract The bile salt export pump (BSEP/Bsep/ABCB11) and multidrug resistance‐associated protein 2 (MRP2/Mrp2/ABCC2) are involved in bile acid‐dependent and ‐independent bile secretion, respectively. It has been reported that bosentan, an endothelin receptor antagonist, inhibits Bsep, which may
Ethanol consumption alters expression and colocalization of bile salt export pump and multidrug resistance protein 2 in the rat
✍ Scribed by Vadim Zinchuk; Olga Zinchuk; Kunihiro Akimaru; Fumio Moriya; Teruhiko Okada
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 444 KB
- Volume
- 127
- Category
- Article
- ISSN
- 1432-119X
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We have studied regulation of the multidrug resistance protein 2 (mrp2) during bile duct ligation (BDL) in the rat. In hepatocytes isolated after 16, 48, and 72 hours of BDL, mrp2-mediated dinitrophenyl-glutathione (DNP-GS) transport was decreased to 65%, 33%, and 33% of control values, respectively
Effect of ursodeoxycholic acid (UDCA) treatment on the expression and function of intestinal multidrug resistance-associated protein (Mrp) 2 was examined in rats. When rats were orally administered 0.5% UDCA solution for 6 days, mRNA and protein levels of Mrp2 in the intestine were increased about t