The liver plays a major role in biotransformation and elimination of various therapeutic agents and xenobiotics, many of which are organic cations and substrates of the organic cation transporter 1 (Oct1, Slc22a1). Oct1 is expressed at the basolateral membranes of hepatocytes and proximal renal tubu
✦ LIBER ✦
Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver
✍ Scribed by Thera A. Vos; Guido J. Hooiveld; Hans Koning; Sarah Childs; Dirk K. Meijer; Han Moshage; Peter L. Jansen; Michael Müller
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 602 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0270-9139
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We have studied regulation of the multidrug resistance protein 2 (mrp2) during bile duct ligation (BDL) in the rat. In hepatocytes isolated after 16, 48, and 72 hours of BDL, mrp2-mediated dinitrophenyl-glutathione (DNP-GS) transport was decreased to 65%, 33%, and 33% of control values, respectively