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Involvement of P-glycoprotein, Multidrug Resistance Protein 2 and Breast Cancer Resistance Protein in the Transport of Belotecan and Topotecan in Caco-2 and MDCKII Cells

✍ Scribed by Hong Li; Hyo-Eon Jin; Wooyoung Kim; Yong-Hae Han; Dae-Duk Kim; Suk-Jae Chung; Chang-Koo Shim


Publisher
Springer US
Year
2008
Tongue
English
Weight
296 KB
Volume
25
Category
Article
ISSN
0724-8741

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## Abstract In our present study, a P‐glycoprotein‐EGFP (P‐gp‐EGFP) fusion plasmid was constructed and functionally expressed in HeLa cells to investigate the intracellular localization and trafficking of P‐glycoprotein (P‐gp). Using immunocytochemistry and fluorescent confocal microscopy technique