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Cyclosporin A, tacrolimus and sirolimus are potent inhibitors of the human breast cancer resistance protein (ABCG2) and reverse resistance to mitoxantrone and topotecan

โœ Scribed by Anshul Gupta; Yang Dai; R. Robert Vethanayagam; Mary F. Hebert; Kenneth E. Thummel; Jashvant D. Unadkat; Douglas D. Ross; Qingcheng Mao

Publisher
Springer
Year
2006
Tongue
English
Weight
340 KB
Volume
58
Category
Article
ISSN
0344-5704

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โœ Timothy C. Chambers; Robert L. Raynor; J. F. Kuo ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 750 KB

In this study we show that multidrug-resistant (MDR) human KB-VI cells are highly resistant to the cytotoxicity of okadaic acid and calyculin A, 2 toxins from marine sponges that are potent inhibitors of type-I and type-2A protein phosphatases (PPl and PP2A). Cytotoxicity and colony-forming assays i