Involvement of Intracellular Stores in the Ca2+ Responses to N-Methyl-D-Aspartate and Depolarization in Cerebellar Granule Cells
β Scribed by Peter B. Simpson; R. A. John Challiss; Stefan R. Nahorski
- Book ID
- 111177718
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 430 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0022-3042
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π SIMILAR VOLUMES
The effect of potassium depolarization and N-methyl-D-aspartate (NMDA) on the activity of aspartate aminotransferase (AAT; EC 2.6.1.1), an enzyme suggested to be involved in neurotransmitter glutamate synthesis, was studied in cultured cerebellar granule neurons. Both KCI and NMDA increased AAT acti
Chronic stimulation of cerebellar granule cells with N-methyl-D-aspartate (NMDA) or KCI induces a specific activation of the enzymes directly involved in glutamate neurotransmitter synthesis. Phosphate-activated glutaminase (PAG) activity is enhanced in cultured granule neurons incubated with 150 pM