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Potentiation of N-methyl-d-aspartate-evoked elevation of intracellular Ca2+ concentrations by exogenous glycine in cerebellar granule cells

✍ Scribed by Peter B. Simpson; R.A. John Challiss; Stefan R. Nahorski


Book ID
113398741
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
569 KB
Volume
266
Category
Article
ISSN
0922-4106

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Chronic stimulation of cerebellar granule cells with N-methyl-D-aspartate (NMDA) or KCI induces a specific activation of the enzymes directly involved in glutamate neurotransmitter synthesis. Phosphate-activated glutaminase (PAG) activity is enhanced in cultured granule neurons incubated with 150 pM