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Involvement of free radicals in MPP+ neurotoxicity against rat dopaminergic neurons in culture

โœ Scribed by Yukio Akaneya; Mitsuo Takahashi; Hiroshi Hatanaka


Book ID
116124767
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
460 KB
Volume
193
Category
Article
ISSN
0304-3940

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Methylphenylpyridium ion (MPP+) enhances
โœ H. Sawada; Dr. S. Shimohama; Y. Tamura; T. Kawamura; A. Akaike; J. Kimura ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 788 KB

Parkinson's disease is characterized by chronic progression of dopaminergic neuronal death, the mechanism of which is still unknown. Although methyl-4-phenylpyridium ion (MPP+) or MPP+-like substance, that can reduce mitochondrial complex I activity, is supposed to be a causative agent for Parkinson