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Melatonin protects nigral dopaminergic neurons from 1-methyl-4-phenylpyridinium (MPP+) neurotoxicity in rats

✍ Scribed by Byung K Jin; Dong Y Shin; Mi Y Jeong; Mi R Gwag; Haing W Baik; Kyung S Yoon; Yong H Cho; Wan S Joo; Yong S Kim; Hyung H Baik


Book ID
117476589
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
78 KB
Volume
245
Category
Article
ISSN
0304-3940

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We have studied the effect of a semichronic and acute treatment of phenobarbital on in vivo 1-methyl-4-phenylpyridinium ion- (MPP+)-induced neurotoxicity. A group of rats were intraperitoneally injected for 12 days with phenobarbital (80 mg/Kg of body weight, semichronic treatment) in order to induc