Effects of cyclin-dependent kinase-5 act
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Shirley B. Shelton; Pavan Krishnamurthy; Gail V.W. Johnson
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Article
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2004
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John Wiley and Sons
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English
β 392 KB
## Abstract Cyclinβdependent kinaseβ5 (CDK5), a unique CDK family member, is active primarily in the central nervous system (CNS). Previous studies suggest that CDK5 is proapoptotic and contributes to tau hyperphosphorylation and neurodegeneration in Alzheimer's disease. The objective of this study