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Involvement of cyclin dependent kinase5 activator p25 on tau phosphorylation in mouse brain

✍ Scribed by Akihiko Takashima; Miyuki Murayama; Kaori Yasutake; Hiroshi Takahashi; Minesuke Yokoyama; Koichi Ishiguro


Book ID
117471796
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
504 KB
Volume
306
Category
Article
ISSN
0304-3940

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Effects of cyclin-dependent kinase-5 act
✍ Shirley B. Shelton; Pavan Krishnamurthy; Gail V.W. Johnson πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 392 KB

## Abstract Cyclin‐dependent kinase‐5 (CDK5), a unique CDK family member, is active primarily in the central nervous system (CNS). Previous studies suggest that CDK5 is proapoptotic and contributes to tau hyperphosphorylation and neurodegeneration in Alzheimer's disease. The objective of this study