Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35
✍ Scribed by Petri Kerokoski; Tiina Suuronen; Antero Salminen; Hilkka Soininen; Tuula Pirttilä
- Book ID
- 117385986
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 449 KB
- Volume
- 106
- Category
- Article
- ISSN
- 0169-328X
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## Abstract Cyclin‐dependent kinase 5 (cdk5), in contrast to other members of the cyclin‐dependent kinase family, is not activated by cyclins but instead is activated by complexing with neuron‐specific activator molecules (p35, p39, and p67). The most effective activator of cdk5 both in vitro and i
## Abstract Although protein kinase Cdk5–p35 is important in many aspects of the development and function of the central nervous system, relatively little is known about its regulation. In the present study, we examined the relationship between the association of this kinase with membranes and its