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5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5

✍ Scribed by Chu, Jin; Praticò, Domenico

Book ID
122961881
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
695 KB
Volume
34
Category
Article
ISSN
0197-4580

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## Abstract Cyclin‐dependent kinase‐5 (CDK5), a unique CDK family member, is active primarily in the central nervous system (CNS). Previous studies suggest that CDK5 is proapoptotic and contributes to tau hyperphosphorylation and neurodegeneration in Alzheimer's disease. The objective of this study