Involvement of caspase-8, -9, and -3 in high glucose-induced apoptosis in PC12 cells
β Scribed by Ali. M. Sharifi; Habib Eslami; Bagher Larijani; Jamshid Davoodi
- Book ID
- 116771330
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 432 KB
- Volume
- 459
- Category
- Article
- ISSN
- 0304-3940
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## Abstract Our previous study showed that cobalt chloride (CoCl~2~) could induce PC12 cell apoptosis and that the CoCl~2~βtreated PC12 cells may serve as a simple in vitro model for the study of the mechanism of hypoxiaβlinked neuronal disorders. The aim of this study is to elucidate the mechanism
Activation of proteolytic enzymes, including the caspase family of proteinases, is a feature characteristic of the apoptotic program. In the present study, we examined a potential role of intracellular proteinases in the death of neuronal PC12 and primary cultured rat microglial cells induced by 6-h