The sequence of the exon I lintron I boundary region of the MYC gene was determined in two diffuse large cell lymphomas (DLCL), one with t(8; 14) (q24q32) and the other with t(8;22) (q24;q I I). Both tumors had multiple mutations in this region. Also, both tumors had mutations in the protein binding
β¦ LIBER β¦
Involvement of c-myc oncogene in lymphoma cell lines with no detectable chromosome rearrangement of band 8q24
β Scribed by Hitoshi Ohno; Shirou Fukuhara; Shoichi Doi; Ryuichi Amakawa; Mitsuru Horii; Yu-ichi Akiyama; Wataru Fukuda; Tasuku Honjo; Taketoshi Sugiyama; Haruto Uchino
- Book ID
- 119104159
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 571 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0165-4608
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## Abstract An ouabainβ and thioguanineβresistant subline (TIKAUT) of spontaneous AKR lymphoma, TKA, was trisomic for chromosome 15 and contained a single 33 kb EcoRI fragment, containing the oncogene __cβmyc__. The original TKA lymphoma and derived __in vitro__ line contained the same 33 kb fragme
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