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Involvement of c-myc oncogene in lymphoma cell lines with no detectable chromosome rearrangement of band 8q24

✍ Scribed by Hitoshi Ohno; Shirou Fukuhara; Shoichi Doi; Ryuichi Amakawa; Mitsuru Horii; Yu-ichi Akiyama; Wataru Fukuda; Tasuku Honjo; Taketoshi Sugiyama; Haruto Uchino


Book ID
119104159
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
571 KB
Volume
40
Category
Article
ISSN
0165-4608

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πŸ“œ SIMILAR VOLUMES


Hypermutation of the MYC gene in diffuse
✍ John F. Bradley; Paul G. Rothberg; Marc Ladanyl; R. S. K. Chaganti πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 303 KB πŸ‘ 1 views

The sequence of the exon I lintron I boundary region of the MYC gene was determined in two diffuse large cell lymphomas (DLCL), one with t(8; 14) (q24q32) and the other with t(8;22) (q24;q I I). Both tumors had multiple mutations in this region. Also, both tumors had mutations in the protein binding

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## Abstract An ouabain‐ and thioguanine‐resistant subline (TIKAUT) of spontaneous AKR lymphoma, TKA, was trisomic for chromosome 15 and contained a single 33 kb EcoRI fragment, containing the oncogene __c‐myc__. The original TKA lymphoma and derived __in vitro__ line contained the same 33 kb fragme