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Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes

✍ Scribed by Marc Le Vee; Elodie Jouan; Olivier Fardel


Book ID
116920294
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
442 KB
Volume
24
Category
Article
ISSN
0887-2333

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## Abstract Epidemiological and laboratory studies suggested that exposure to 2,3,7,8‐tetrachlorodibenzo‐__p__‐dioxin (TCDD) affects glucose homeostasis and increases the incidence of type 2 diabetes mellitus. To evaluate the effects of TCDD on insulin secretion from islets of Langerhans (islets),