Recent advances in low-frequency sonophoresis have focused on the existence of hypothesized localized transport regions (LTRs). However, there has been no actual experimental demonstration that the hypothesized LTRs are, in fact, localized regions of high permeability. Through a series of low-freque
Investigations of the role of cavitation in low-frequency sonophoresis using acoustic spectroscopy
โ Scribed by Ahmet Tezel; Ashley Sens; Samir Mitragotri
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 168 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
โฆ Synopsis
Application of low-frequency ultrasound signiยฎcantly enhances skin permeability. The enhancement of skin permeability is mediated by cavitation, oscillation, and collapse of gaseous cavities. In this article, we report detailed investigations of the occurrence of cavitation during low-frequency sonophoresis. Cavitation was monitored by recording pressure amplitudes of subharmonic emission and broadband noise at four different ultrasound frequencies in the range of 20ยฑ100 kHz and at various intensities in the range of 0ยฑ2.6 W/cm 2 . Enhancement of skin conductivity, in the presence of sodium lauryl sulfate (SLS), was also measured under the same ultrasound conditions. Enhancement of skin conductivity correlated well with the amplitude of broadband noise, which suggests the role of transient cavitation in low-frequency sonophoresis. No correlation was found between the subharmonic pressure amplitude and conductivity enhancement.
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