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Investigations of the role of cavitation in low-frequency sonophoresis using acoustic spectroscopy

โœ Scribed by Ahmet Tezel; Ashley Sens; Samir Mitragotri


Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
168 KB
Volume
91
Category
Article
ISSN
0022-3549

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โœฆ Synopsis


Application of low-frequency ultrasound signiยฎcantly enhances skin permeability. The enhancement of skin permeability is mediated by cavitation, oscillation, and collapse of gaseous cavities. In this article, we report detailed investigations of the occurrence of cavitation during low-frequency sonophoresis. Cavitation was monitored by recording pressure amplitudes of subharmonic emission and broadband noise at four different ultrasound frequencies in the range of 20ยฑ100 kHz and at various intensities in the range of 0ยฑ2.6 W/cm 2 . Enhancement of skin conductivity, in the presence of sodium lauryl sulfate (SLS), was also measured under the same ultrasound conditions. Enhancement of skin conductivity correlated well with the amplitude of broadband noise, which suggests the role of transient cavitation in low-frequency sonophoresis. No correlation was found between the subharmonic pressure amplitude and conductivity enhancement.


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