Investigations of (4-cyanophenyl)ureas of sweet amino acids as potential sweeteners
✍ Scribed by Hallinan, E. Ann; Walters, D. Eric; DuBois, Grant E.; Mazur, Robert H.; Muller, George W.
- Book ID
- 127275544
- Publisher
- American Chemical Society
- Year
- 1991
- Tongue
- English
- Weight
- 333 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0021-8561
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## Abstract Starting from 5‐bismethylthiomethylene Meldrum's acid, the synthesis of 5‐diaminomethylene Meldrum's acids and 2‐aminoquinolone derivatives, structurally related to potassium channels openers pinacidil and diazoxide, is described.
## Abstract __o__‐Aminoamide **8**, an intermediate in our multistep synthesisof the title compounds was prepared from 1,3‐diketone **3**. The following condensation of **8** with chloroformamidine‐HCl (**9**) gave pyrido[3,4‐__d__]pyrimidine **10**. Dehydratisation of amide **8** led to __o__‐amin