𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Investigation of the major human hepatic cytochrome P450 involved in 4-hydroxylation and N -dechloroethylation of trofosfamide

✍ Scribed by Antje May-Manke; Heyo Kroemer; Georg Hempel; Frank Bohnenstengel; Barbara Hohenlöchter; Gottfried Blaschke; Joachim Boos


Publisher
Springer
Year
1999
Tongue
English
Weight
162 KB
Volume
44
Category
Article
ISSN
0344-5704

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Endotoxin suppresses the oltipraz-mediat
✍ Karine Mahéo; Fabrice Morel; Jocelyne Antras-Ferry; Sophie Langouët; Fabienne De 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 239 KB 👁 1 views

the Association pour la Recherche sur le Cancer, and the European Economic Communities (BIOMED; contract BMH4-CT96-0254). Karine Mahe ´o is a recipient of a fellowship from the Ministe `re de la Recherche et de l'Enseignement Supe ´rieur, and Sophie Langoue ¨t is a recipient of a fellowship from th

Hepatic disposition of the cytochrome P4
✍ Reza Mehvar; Ragini Vuppugalla 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 178 KB

The steady-state disposition of chlorzoxazone (CZX) and its hydroxylated metabolite 6-hydroxychlorzoxazone (HCZX) was determined in a single-pass isolated perfused rat liver (IPRL) model using constant CZX concentrations of 10-200 microM. The concentrations of CZX, HCZX, and/or HCZX glucuronide in t

Hydroxylation of diclofenac: an illustra
✍ Samya Othman; Virginie Mansuy-Mouries; Claude Bensoussan; Pierrette Battioni; Da 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 200 KB

Preparative hydroxylation of aromatic compounds such as drugs remain a difficult challenge. Here we show that the two main human metabolites of the anti-inflammatory drug diclofenac, 5-hydroxy-and 4%-hydroxy-diclofenac, can be prepared from diclofenac in high yields by using two complementary model

Human hepatic and renal microsomes, cyto
✍ Marie Stiborová; Eva Frei; Petr Hodek; Manfred Wiessler; Heinz H. Schmeiser 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 139 KB

## Abstract Aristolochic acid (AA), a naturally occurring nephrotoxin and carcinogen, has been associated with the development of urothelial cancer in humans. Understanding which human enzymes are involved in AA activation and/or detoxication is important in the assessment of an individual's suscep