## Abstract Cytochrome P450 (CYP) substrates that yield fluorescent metabolites were used for rapid screening of drug metabolism activities of 13 recombinant human cytochromes P450, human liver microsomes and human hepatocytes. Reproducible results were obtained using a fluorescent plate reader (Cy
Activities of human recombinant cytochrome P450 isoforms and human hepatic microsomes for the hydroxylation ofAlternariatoxins
✍ Scribed by E. Pfeiffer; B. Burkhardt; M. Altemöller; J. Podlech; M. Metzler
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- English
- Weight
- 108 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0178-7888
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Previous studies have established that chlorpyrifos (CPS), fipronil, and nonane can all be metabolized by human liver microsomes (HLM) and a number of cytochrome P450 (CYP) isoforms. However, metabolic interactions between these three substrates have not been described. In this study th
A simple and rapid method for the determination of (S)-mephenytoin 4-hydroxylase activity by human liver microsomal cytochrome P-450 has been developed. [Methyl-'4C]mephenytoin was synthesized by alkylation of Snirvanol with 14CHJ and used as a substrate. AAer incubation of [mefhy/-'4C]mephenytoin w