✦ LIBER ✦

Investigation of the effect of a dc glow discharge on the performance of a particle beam liquid chromatography/mass spectrometry interface

✍ Scribed by Thomas A. Bellar; William L. Budde; David D. Kryak

Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 407 KB
Volume: 5
Category: Article
ISSN: 1044-0305
DOI: 10.1016/1044-0305(94)87016-0

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✦ Synopsis

A low voltage (180-V) dc glow discharge device was inserted just below the pneumatic nebulizer in a particle beam interface of a high performance liquid chromatography/mass spectrometry system. The discharge in a helium atmosphere increased the signal produced by 12 test compounds by factors of about 2-6. The increases in signal were probably produced by an increase in the efficiency of solute transmission through the interface. The signal increases caused by the glow discharge were compared to somewhat larger increases caused by 0.01-M ammonium acetate in the mobile phase. The combination of glow discharge and ammonium acetate provided no meaningful advantage over the individual techniques. The mechanism of improved transport efficiency is not proven, but the neutralization of charged particles is a viable hypothesis.

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