✦ LIBER ✦

Optimization of the Hewlett-Packard particle-beam liquid chromatography-mass spectrometry interface by statistical experimental design

✍ Scribed by S.K. Huang; N.R. Garza

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 593 KB
Volume: 6
Category: Article
ISSN: 1044-0305
DOI: 10.1016/1044-0305(95)00055-i

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✦ Synopsis

Optimization of both sensitivity and ionization softness for the Hewlett-Packard particle-beam liquid chromatography-mass spectrometry interface has been achieved by using a statistical experimental design with response surface modeling. Conditions for both optimized sensitivity and ionization softness were found to occur at 55-lb/in.(2) nebulizer flow, 35°C desolvation chamber temperature with approximately 45% organic modifier in the presence of 0.02-F ammonium acetate and a liquid chromatography flow rate of 0.2 mL/min.

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