Investigation of new chiral 1,3-oxazolidine-2-thiones: analytical separation and optical resolution of racemic carboxylic acids and amino acids
✍ Scribed by Nagao, Yoshimitsu; Kumagai, Toshio; Yamada, Shozo; Fujita, Eiichi; Inoue, Yoshinori; Nagase, Yunosuke; Aoyagi, Sakae; Abe, Takao
- Book ID
- 121204690
- Publisher
- Royal Society of Chemistry
- Year
- 1985
- Weight
- 944 KB
- Category
- Article
- ISSN
- 1472-7781
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## Abstract Site selective mono‐ and dimetalation methods have been developed for the functionalization of 1‐[(1,1′‐biphenyl)‐2‐yl]‐1H‐pyrrole. Optical resolution of the prepared 1‐[(3‐carboxy‐1,1′‐biphenyl)‐2‐yl]pyrrole‐2‐carboxylic acid provided new atropisomeric 1‐arylpyrrole derivatives. The ab
The reaction of chiral 2-trifluoromethyl-1,3-oxazolidines with various silylated nucleophiles under Lewis acid activation provides a stereoselective route to functionalized a-trifluoromethylamines. This methodology was successfully applied to the diastereoselective synthesis of trifluoromethylated h