✦ LIBER ✦

Synthesis and optical resolution of 1-[(3-carboxy-1,1′-biphenyl)-2-yl]-1H-pyrrole-2-carboxylic acid

✍ Scribed by Ferenc Faigl; Bernadett Vas-Feldhoffer; Veronika Kudar; Mátyás Czugler; Krisztina Pál; Miklós Kubinyi

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 295 KB
Volume: 21
Category: Article
ISSN: 0899-0042
DOI: 10.1002/chir.20686

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✦ Synopsis

Abstract

Site selective mono‐ and dimetalation methods have been developed for the functionalization of 1‐[(1,1′‐biphenyl)‐2‐yl]‐1H‐pyrrole. Optical resolution of the prepared 1‐[(3‐carboxy‐1,1′‐biphenyl)‐2‐yl]pyrrole‐2‐carboxylic acid provided new atropisomeric 1‐arylpyrrole derivatives. The absolute configuration of the pure dicarboxylic acid enantiomers was determined by single crystal X‐ray diffraction and CD spectroscopy. Chirality 2009. © 2009 Wiley‐Liss, Inc.

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