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Investigation of nanocapsules stabilization by amorphous excipients during freeze-drying and storage

โœ Scribed by Wassim Abdelwahed; Ghania Degobert; Hatem Fessi

Book ID
116437520
Publisher
Elsevier Science
Year
2006
Tongue
French
Weight
441 KB
Volume
63
Category
Article
ISSN
0939-6411

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Mechanism of protein stabilization by sugars during freeze-drying and storage: Native structure preservation, specific interaction, and/or immobilization in a glassy matrix?
โœ Liuquan (Lucy) Chang; Deanna Shepherd; Joanna Sun; David Ouellette; Kathleen L. ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 328 KB ๐Ÿ‘ 1 views

The purpose of this study is to investigate the mechanism of protein stabilization by sugars in the solid state. That is, explore whether the stabilization is controlled by "glass dynamics" or by native structure preservation through "specific interaction" between sugars and protein. The IgG1 antibo