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Investigation of ischemia damaging action on blood serum by Raman spectroscopy method

โœ Scribed by A. N. Baranov; I. M. Vlasova; A. M. Saletsky

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
172 KB
Volume
1
Category
Article
ISSN
1612-2011

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โœฆ Synopsis

Raman spectroscopy method is applied for analysis of ischemia damaging action on serum. The registered changes of low-density lipoprotein (LDL) after brain ischemia (size increasing, density reducing) are explained in frameworks of free radical theory of oxidative stress. We confirmed by Raman spectroscopy method our hypothesis, according to which the increase in LDL size and decrease of LDL density after an ischemia, in contrast to LDL of healthy animals, is caused by loosing of LDL phospholipid monolayer under damaging action of free radicals. The obtained results show the possibility of using of Raman spectroscopy method for an estimation of ischemic damages.

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