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Investigation of CsCl-induced aggregation of serum albumin depending on pH by Raman spectroscopy method

✍ Scribed by I. M. Vlasova; V. E. Mikrin; A. M. Saletsky

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 129 KB
Volume: 2
Category: Article
ISSN: 1612-2011
DOI: 10.1002/lapl.200410159

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✦ Synopsis

The evidence of human serum albumin aggregation at the presence of heavy metal salt (CsCl) is obtained by the Raman spectroscopy method. It is shown, that the strongest aggregation of albumin takes place near to albumin isoelectric point (at pH 5.0). Also the amino acidic mechanism of aggregation is explained, and aggregating chemical bonds arising between residues of amino acids are found out.

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