Investigation of Enantiomeric Separation of Chiral Drugs by CE Using Cu(II)–Clindamycin Complex as a Novel Chiral Selector
✍ Scribed by Jianfeng Wu; Peng Liu; Qingwei Wang; Hui Chen; Peng Gao; Li Wang; Shengyong Zhang
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 540 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0009-5893
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## Abstract This paper deals with the use of Cu(II) complexes of L‐tartaric acid or L‐threonine as selectors for the chiral separation of drugs containing amino alcohol structure by ligand‐exchange CE. Using Cu(II) ions as a complexing agent, a series of sympathomimetics and β‐blockers were resolve
## Abstract High resolution could be achieved for the enantiomers of acidic drugs, namely, sulindac, fenoprofen, ketoprofen, warfarin, and hexobarbital, in a buffer of pH 3 by the simultaneous addition of uncharged and charged β‐cyclodextrin derivatives. The interaction of the analytes with the ani