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Investigation of doubly charged organic cations by electrospray ion cyclotron resonance mass spectrometry

✍ Scribed by Alan R. Katritzky; Petia A. Shipkova; Richard D. Burton; Steven M. Allin; Clifford H. Watson; John R. Eyler

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
554 KB
Volume
30
Category
Article
ISSN
1076-5174

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✦ Synopsis

Abstract

The production and detection of doubly charged organic cations were studied using a previously unreported approach—electrospray ionization coupled with Fourier transform ion cyclotron resonance mass spectrometry. Owing to its ultra‐high mass resolution, accurate and stable mass calibration, multiple stages of collisionally activated dissociation (CAD) allowing tandem mass spectrometry and extremely long ion storage times (> 1 min), this technique has proven to be a powerful method for the detection and study of doubly charged organic compounds. CAD studies were used for the identification of ion–molecule reactions and for the investigation of the propensity towards gas‐phase S~N~1 and S~N~2 reaction pathways. To date exclusively S~N~1‐type reactions in the gas phase have been detected. Three doubly charged pyridinium salts were chosen as model compounds for this study.

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