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Analysis of Combinatorial Libraries Using Electrospray Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

✍ Scribed by Joseph P. Nawrocki; Maria Wigger; Clifford H. Wilson; Thomas W. Hayes; Michael W. Senko; Steven A. Benner; John R. Eyler

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
522 KB
Volume
10
Category
Article
ISSN
0951-4198

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✦ Synopsis

Electrospray ionization coupled with Fourier transform ion cyclotron resonance (FTICR) m a s spectrometry has been used to provide infonntion about complete combinatorial libraries of small peptides containing l@-104 components. The fidelity of attempted synthesis steps can be ascertained rapidly, and, when the extremely high resolution FTICR mass spectra are combined with appropriate computer simulation, both diversity and degeneracy of the libraries as synthesized can be assessed.

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