✦ LIBER ✦

Investigation of bombolitin complexes with mercury by liquid chromatography/tandem mass spectrometry

✍ Scribed by Marco Garzotti; Luca Rovatti; Mahmoud Hamdan

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 254 KB
Volume: 12
Category: Article
ISSN: 0951-4198
DOI: 10.1002/(sici)1097-0231(19980131)12:2<61::aid-rcm117>3.0.co;2-a

No coin nor oath required. For personal study only.

✦ Synopsis

Solid-phase synthesis of (Cys 3,13 )bombolitin peptide resulted in a crude reaction mixture containing the target peptide as well as a number of unknown products. The use of on-line liquid chromatography coupled to electrospray mass spectrometry (LC/ES-MS) gave a strong indication that these side-products were mainly complexes between the target peptide and mercury which was used in the form of mercury (II) acetate during the synthetic procedure. On-line LC/electrospray tandem mass spectrometry (ES-MS/MS) furnished reliable information on the amino acid sequences of both the target peptide and of the complexes with mercury or with mercury plus the b-mercaptoethanol used to eliminate the mercury at the end of the synthesis.

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