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Determination of Furosine in Hair by Liquid Chromatography–Tandem Mass Spectrometry

✍ Scribed by Akira Takemura; Shigeki Muramatsu; Nobuhiro Kobayashi; Akihiko Nakagawa; Eiichi Kitazawa; Toshihiko Uematsu

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
153 KB
Volume
11
Category
Article
ISSN
0269-3879

No coin nor oath required. For personal study only.

✦ Synopsis

A sensitive and reliable analytical method for determining furosine in hair has been developed using liquid chromatography-tandem mass spectrometry. Fructose-N"-fomyl-d,-DL-lysine was synthesized and used as an internal standard. By the present method, glycated lysine levels in hair could be determined as fructose-lysine in only 0.1 mg of hair sample, ranging fhm 35.1-72.6nglmg hair among five healthy volunteers, which corresponded to 0.0635-0.153% of the total lysine contents in hair determined by amino acid analysis.

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