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Investigation into the involvement of phospholipases A2 and MAP kinases in modulation of AA release and cell growth in A549 cells

✍ Scribed by Qamrul G Choudhury; Diane T Mckay; Roderick J Flower; Jamie D Croxtall


Book ID
110005251
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
386 KB
Volume
131
Category
Article
ISSN
0007-1188

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I 2-0-tetradecanoylphorbol-I 3-acetate (TPA) and bryostatin I are activators of protein kinase C (PKC). TPA is a potent inhibitor of the growth of A549 cells, while bryostatin I exerts a weak antiproliferative effect upon this cell line. We tested the hypothesis that the PKC inhibitor staurosporine