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Involvement of cell cycle regulatory proteins and MAP kinase signaling pathway in growth inhibition and cell cycle arrest by a selective cyclooxygenase 2 inhibitor, etodolac, in human hepatocellular carcinoma cell lines

โœ Scribed by Jidong Cheng; Hiroyasu Imanishi; Weidong Liu; Hideji Nakamura; Takayuki Morisaki; Kazuya Higashino; Toshikazu Hada

Book ID
108583438
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
604 KB
Volume
95
Category
Article
ISSN
1347-9032

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NS-398, a selective cyclooxygenase 2 inh
NS-398, a selective cyclooxygenase 2 inhibitor, inhibited cell growth and induced cell cycle arrest in human hepatocellular carcinoma cell lines
โœ Jidong Cheng; Hiroyasu Imanishi; Yoshiki Amuro; Toshikazu Hada ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 680 KB

## Abstract Cyclooxygenase 2 (COXโ€2) has been suggested to be associated with liver carcinogenesis. Several reports have shown that NSAIDs inhibit the growth of hepatocellular carcinoma cell lines. There is little evidence of how COXโ€2 inhibitors regulate the proliferation of hepatocellular carcino