The reduction of sec-alkyl 2-methyl-3-oxobutyrate with a keto ester reductase from bakers' yeast (YKER-I) is accompanied by simultaneous dynamic and static resolution of chiral centers affording the corresponding (2R,3S,1ЈR)-hydroxy esters preferentially. Thus, the enzyme discriminates three chiral
Introduction of plural asymmetric centers by a β-keto ester reductase from baker's yeast
✍ Scribed by Yasushi Kawai; Kouichi Hida; Kaoru Nakamura; Atsuyoshi Ohno
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 129 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
Asymmetric Synthesis of β-Hydroxy Esters Having Three Consecutive Chiral Centers with a Reductase from Bakers' Yeast. -The title reaction is investigated with β-keto esters (I) having a secondary alkyl group at the α-position. The corresponding β-hydroxy esters can be isolated in excellent enantios
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